Research Studies 1 of 3 Next
line Ovarian Cancer Screening Pilot Study

Research Studies

  Recruitment Currently Closed Stay  Turned for Future Studies

Study Name

Risk of Ovarian Cancer Algorithm (ROCA)

Description

A National Cancer Institute (NCI) multi-center study for women at high risk for ovarian cancer. If you have a family history of breast and/or ovarian cancer, you may be eligible. The goal of the study is to determine the effectiveness of measuring CA125 (blood tumor marker) for the early detection of ovarian cancer.

Eligible candidates must:

Be 30 years of age or older

Never have had ovarian cancer

Have at least one ovary and meet one or more of the following criteria:

Ø Be a carrier of a BRCA 1 / 2 mutation or have a first or second degree relative (sibling, mother, father, grandparent, aunt or uncle) who has tested positive for a BRCA 1 / 2 mutation

                    OR

Ø Have a family that contains at least 2 ovarian or breast cancers* among first and second-degree relatives on the same side of the family. Multiple primaries in the same person satisfy this condition.

                    OR

Ø Be of Ashkenazi Jewish ethnicity with one first or two second-degree relatives with breast or ovarian cancer, or have had breast cancer* yourself.

* Where breast cancer is required to meet the eligibility, at least one breast cancer must be pre-menopausal (age at diagnosis <50 if age at menopause is unknown)

        Participants will:
  • review and sign a study consent form
  • complete two 30-40 minute questionnaires about medical history, health habits, disease symptoms, screening tests,  and demographics
  • sign a medical records release form for review of medical information
  • provide a blood sample every three months and complete a brief questionnaire
  • if indicated by your CA125 results, have a transvaginal ultrasound
  • complete a comprehensive 30-40 minute annual questionnaire about changes in family history, medications, and health status

Principal Investigator
Deborah K. Armstrong, MD

Contact Information
Judy Bacon
Study Coordinator
(410) 502-7660 or 1-877-880-6188 (toll-free)
e-mail: baconju@jhmi.edu


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