Cancer Genetics Resources at Johns Hopkins

The Johns Hopkins Cancer Risk Assessment Program
(410) 614-6319
Risk Assessment / Diagnosis / Genetic Counseling
Genetic Testing / Management Recommendations

Breast and Ovarian Surveillance Service (BOSS)

Patients diagnosed with:

Breast and ovarian cancer or multiple primary breast cancers

Individuals with a family history of:

A blood relative with a known BRCA1/2 gene mutation
Two first or second degree relatives with breast cancer diagnosed <50 years
Three first or second degree relatives with breast cancer with at least one relative diagnosed <50 years
Two first or second degree relatives with ovarian cancer
Breast cancer in at least one first or second degree relative and ovarian cancer in at least one first or second degree relative

An Ashkenazi Jewish woman with breast cancer diagnosed <40 years or ovarian cancer at any age

Patients who would like:

To learn about breast cancer prevention and screening
A breast examination and instruction on self-breast examinations

Familial Cancer Service

Patients diagnosed with:

Multiple primary cancers
Cancer at an unusually young age

Individuals with a family history of:

A clustering of rare or unusual cancers
Any known cancer susceptibility syndrome
One or more first degree relatives with cancer

Colon Cancer Risk Assessment Service

Patients diagnosed with:

Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
Familial Adenomatous Polyposis (FAP)
APC I1307K gene mutation
Colorectal cancer <55 years
Colorectal adenoma <40 years
Endometrial cancer <45 years
Two HNPCC-related cancers*, including synchronous and metachronous colorectal cancer
Multiple adenomatous polyps <50 years
Juvenile Polyposis, Peutz Jeghers or other hereditary colorectal cancer syndrome

Individuals with a family history of:

A blood relative with a known HNPCC or FAP gene mutation
Colorectal cancer in several relatives or two successive generations

An individual with colorectal cancer and a first-degree relative with colorectal cancer or an HNPCC-related cancer* - one of the cancers diagnosed <45 years

*HNPCC-related cancers include colorectal, endometrial, stomach, biliary tract, urinary tract, and ovarian